【實驗動物購買SAMP8小鼠快速老化SAMP8小鼠價格優】

快速老化早老小鼠samp8小鼠購買、samr1小鼠購買部分用戶：寧夏醫科大學(SAMP8小鼠購買)、中國中醫科學院(SAMP8小鼠購買)、北京中醫藥大學（SAMP8小鼠購買）、同濟醫院（SAMP8小鼠購買）、中科院遺傳與發育研究所（SAMP8小鼠購買及藥效試驗藥代動力學毒理實驗創新藥物臨床前研究安全性評價、取材取組織及行為學動物實驗外包服務）、北京師范大學（SAMP8小鼠）、國家體育總局體育科學研究所Samp8小鼠購買及藥效試驗藥代動力學毒理實驗創新藥物臨床前研究安全性評價、取材取組織及行為學動物實驗外包服務、河北醫科大學，中國醫科大學、山東大學、齊魯醫院、復旦大學、瑞金醫院、中科院上海藥物研究所、上海交通大學、第二軍醫大學、第四軍醫大學、中科院生物物理所、南方醫科大學、武漢協和、中國醫學科學院等均使用本單位提供快速老化早老小鼠samp8小鼠動物進行研究，raacaa@163.com

有各月齡SPF級快速老化早老小鼠SAM-P8小鼠SAM-P8mice小鼠購買價格優惠，SPF級快速老化SAM-R1小鼠SAM-P8mice小鼠購買價格優惠，保質保量，提供質量合格證，可送貨到實驗室，提供實驗動物模型快速老化小鼠samp8小鼠實驗動物模型及藥效試驗藥代動力學毒理實驗創新藥物臨床前研究安全性評價、取材取組織及行為學動物實驗外包服務，aiacaa@163.com

快速老化小鼠SAMP8小鼠SAMR1小鼠起源 1968年，美國（Bar Harber ME）JAX贈送給日本京都（Kyoto）大學幾對AKR/J系小鼠。在繁殖飼養過程中，Takeda等人發現有幾窩小鼠表現有程度不同的脫毛、皮膚粗糙、白內障、行為障礙及生存期縮短等現象，且具有遺傳傾向。1975年，他們精心挑選了5窩表現明顯衰老的AKR/J小鼠作為P系祖先，表現有正常衰老過程的小鼠作為R系祖先。選擇P系、R系的主要標準是以老化度評分（在8月齡時衰老程度）、生存期限及與衰老相關疾病的病理學改變為依據。根據生存曲線（Gompertzian function）及老化度評分標準得出P系小鼠的衰老特征為快速老化。因此，P系稱為快速老化小鼠（Senescence accelerated mouse/prone， SAMP），R系稱為抗快速老化小鼠。至善健康醫學研究院引入培育。

快速老化小鼠SAMP8小鼠SAMR1小鼠特征與快速老化小鼠SAMP8小鼠SAMR1小鼠用途

◇快速老化小鼠SAMP8小鼠購買后在增齡過程中腦內有大量Aβ沉積，Northern雜交法檢測表明，β淀粉樣蛋白前體(APP)mRNA表達水平無明顯變化。

◇快速老化小鼠SAMP8小鼠購買后在增齡過程中出現的學習記憶功能障礙與腦內相應神經遞質改變密切相關，如大腦皮層和海馬部位乙酰膽堿(Ach)、去甲腎上腺素(NE)、多巴胺(DA)降低及阿片肽、γ-氨基丁酸(GABA)升高，5-羥色胺(5-HT)表現為先升高后降低等。

◇快速老化小鼠SAMP8小鼠購買在2月齡時就出現免疫功能異常，對綿羊紅細胞(SRBC)誘導的脾細胞抗體生成反應、Con A誘導的淋巴細胞增殖反應及IL-2產生能力均明顯下降。進一步研究發現，快速老化小鼠SAMP8小鼠脾臟CD+4細胞數目及功能下降，NK細胞數量正常。用免疫增強劑后，NK細胞活性明顯增強，表明NK細胞活性降低可能與IL-2水平下降有關。

◇快速老化小鼠SAMP8小鼠購買用途：研究衰老與學習記憶功能及學習記憶功能障礙發生機制和評價益智藥物的良好動物模型，而且快速老化小鼠SAMP8小鼠是研究神經內分泌免疫調節網絡平衡的良好模型。

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STRAIN NAME: Senescence accelerated mouse/prone8
TYPE: Spontaneous mutation
BACKGROUND STRAIN: AKR/J
COAT COLOR: White (Albino)
ORIGIN: In 1968, the United States (Bar Harber ME) Jackson laboratory presented to a few of the AKR / J mice the in Kyoto, Japan (Kyoto) University,.in Feeding and breeding process, Takeda found several mice showed different degrees epilation, rough skin, cataracts, behavioral disorders and shortened survival phenomena and have a genetic predisposition. In 1975, they carefully selected the five nest obvious aging AKR / J mice as the P series ancestors, normal aging process of mice as the R line ancestor. Select the P series, R series main criteria for degree of aging (in 8 mon degree of aging), survival period and pathological changes based on diseases associated with aging. According to the survival curve (Gompertzian function) and degree of aging get P series mice as rapid aging [1]. Therefore, P series called senescence accelerated mouse (Senescence accelerated mouse / prone, SAMP), R series known as the anti-senescence accelerated mouse.
Biology: SAMP 8 brain have a large number of Aβ deposition in the aging process. Northern hybridization analysis showed that, β-amyloid precursor protein (APP) mRNA expression did not change significantly. SAMP 8 occurred learning, memory dysfunction and Neurotransmitter change in the brain during the aging, such as the cerebral cortex and hippocampus of acetylcholine (Ach), norepinephrine (NE), dopamine (DA) and opioid peptides reduce, γ-aminobutyric acid (GABA) increased, 5 - hydroxytryptamine (5-HT) showed first increased and then decreased and so on. SAMP 8 at 2 mon occurs immune dysfunction ,the sheep red blood cells (SRBC)-induced spleen cell antibody response, Con A-induced lymphocyte proliferation and IL-2 production capacity decreased significantly. Further study found that SAMP8 CD+4 cells decreased and function decline in the spleen, NK cells normal. NK cell activity was significantly enhanced After using immunostimulants, NK cell activity decreased possible relate with IL-2 levels decline.
RESEARCH APPLICATION: learning and memory dysfunction, Evaluation of anti-aging and improve learning and memory drugs

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